AB4AD

Antibodies for Alzheimer's Disease

78.834 ETH raised for groundbreaking Alzheimer's research

Join our community to participate in governance and shape the future of Alzheimer's research.

125
Funders
78.834
ETH Raised
1
Research Project

About AB4AD

Project Tokenization

AB4AD is pioneering the future of research funding through intellectual property tokens (IPTs). These aren't just ordinary tokens - they represent fractional governance rights over the intellectual property generated through this research. As a token holder, you can participate in key research decisions and help shape the future of Alzheimer's research.Learn more about IPTs.

Our project has been fundraised through the Molecule platform, which connects researchers with decentralized funding for breakthrough scientific projects.

Backed by Leading Organizations

VitaDAO$50,000 USD

Our project has received backing from VitaDAO, a leading decentralized science (DeSci) organization with a mission to radically extend healthy human lifespan by funding cutting-edge aging research. As one of the most prominent players in the DeSci movement, VitaDAO's $50,000 USD funding validates our innovative approach to combining scientific research with web3 technology.

The Problem

Alzheimer's Disease (AD) is the major cause of dementia, responsible for 60-70% of cases, leading to irrevocable memory loss and behavior changes. Prior studies have shown a link between germ exposure, immune response, and the probability of developing AD, known as 'The Pathogen Hypothesis'.

Despite a body of evidence, this angle has been under-explored due to the current focus on protein aggregation in the AD research world.

Our Solution

We are looking to understand how specific individuals remain dementia-free well into their 90s and 100s, despite being exposed to those same pathogens. Our research focuses on testing saliva and blood samples from elderly individuals without dementia for antibodies against these germs.

These results will be used to create an AD diagnostic tool that will enable cheap, non-invasive, early diagnosis of asymptomatic individuals.

The AB4AD Story

Expert Researchers

Under the leadership of Dr. Daniel Z. Bar from Tel Aviv University, our research team is pioneering innovative approaches to understanding and combating Alzheimer's Disease.

With extensive experience in neurodegenerative disease research, our team brings together expertise in immunology, neuroscience, and biotechnology.

Research Lab

The Research Journey

Having learnt about the overwhelming evidence that supports the Pathogen Hypothesis, we have dedicated ourselves to unravelling the causes behind Alzheimer's development. Two pathogens of special interest emerged: herpes (the common cold sore) and P.gingivalis (gum disease), both shown to significantly impact AD risk.

Through our partnership with Fliman Geriatric Hospital and the university's dental school, we've already identified promising differences in antibody levels between AD and non-AD samples.

Laboratory Research

Future Vision

Our research aims to develop two groundbreaking solutions: a diagnostic tool for early AD detection and a potential vaccine. The diagnostic tool will enable non-invasive, early diagnosis of asymptomatic individuals, while our long-term goal focuses on vaccine development.

With $192,570 USD in funding, we'll expand our sample screening, perform advanced VirScan analysis, and validate protein-protein interactions crucial to the immune response.

Future of Medicine

Commercial Potential

Our commercialization strategy follows a two-step approach: first, developing a diagnostic tool for quick market entry, followed by vaccine development. This approach allows us to generate early revenue while gathering crucial data for vaccine research.

We're securing patents for our diagnostic kit components and future vaccine development, ensuring long-term value for our stakeholders while advancing global healthcare.

Medical Innovation

Progress Update - March 25th